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TUDCA has been used as a supplement in traditional Chinese medicine for thousands of years. It is originally derived from bear bile and consists of 50% TUDCA. Today, this health-promoting supplement is synthetic.

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What is TUDCA?

Taurine deoxycholic acid is a naturally occurring water-soluble bile acid. Bacteria in the large intestine break down bile salts and turn them into ursodeoxycholic acid (UDCA). It then combines with taurine molecules to create TUDCA.

TUDCA has been used as a supplement in traditional Chinese medicine for thousands of years. It is originally derived from bear bile and consists of 50% TUDCA. Today, this health-promoting supplement is synthetic.

Product Name TUDCA
CAS No. 14605-22-2
Appearance white powder
Specifications 99%
Pakage 1kg/bag, 25kg/drum
Storage Moisture-roof and avoid light, sealed storage.
Test Method HPLC

Benefits of TUDCA

TUDCA supplements have been shown to provide many health benefits to the liver and gastrointestinal system, but surprisingly, TUDCA has dozens of other benefits that extend far beyond the digestive system.

Preclinical studies show that TUDCA is neuroprotective, anti-inflammatory, anti-diabetic, and has many more health-promoting properties.


Reduce bile sludge (cholestasis)

TUDCA was found in clinical trials to have a strong effect as a bile acid, improving cholestasis by reducing bile sludge. Symptoms of cholestasis may include dark urine, light-colored stools, and severe itching.


Improve digestion

TUDCA helps enhance bile flow, which promotes healthy digestion and absorption of dietary fats. Research shows that TUDCA not only increases bile flow, but also improves the chemical composition of bile so that it contains more compounds that aid digestion.

Acid reflux damages the stomach lining over time because stomach acid is very acidic. TUDCA improves gastric wall damage caused by bile reflux. Dr. Berg also recommends drinking ACV (apple cider vinegar) every day while on the ketogenic diet.


Promote gut health

TUDCA supports a healthy intestinal lining, preventing and improving leaky gut syndrome. Leaky gut is a common digestive disorder that involves damage to the intestinal lining. Long-term damage from leaky gut can lead to intestinal permeability. This means that substances that should remain in the digestive tract can escape or leak out.

Common factors that lead to leaky gut include stress and poor diet. Environmental pollutants, such as pesticides, are also thought to contribute to leaky gut syndrome.


Supports a healthy cardiovascular system

TUDCA helps break down and remove excess cholesterol from the body. TUDCA alters hepatic cholesterol metabolism. One small human study found that taking 1,000 to 1,500 mg of TUDCA daily for six months reduced total cholesterol levels.

TUDCA also promotes healthy blood vessels. Research shows that TUDCA recruits angiogenic progenitor cells and can accelerate the repair and formation of blood vessels.


Stabilize mitochondria

TUDCA helps support mitochondrial health. Mitochondria are the energy-producing parts of human cells. Mitochondria provide energy to cells. When mitochondria don’t work properly, cell death occurs.

Normal/programmed cell death is an important body process; when cells are damaged or not needed, TUDCA removes them.

Some disease processes can lead to untimely cell death. Mitochondria are a part of the cell that are particularly involved in cell death by apoptosis. Both taurodeoxycholic acid (TUDCA) and ursodeoxycholic acid (UDCA) disrupt the mitochondrial pathway of cell death.


Reduce inflammation

Research on neuroinflammation has found that TUDCA has anti-inflammatory effects on glial cells. Glial cells promote the development of new neurons. Glial cells are found in the central nervous system (brain and spine).

Glia cells are smaller and more numerous than neurons (nerve cells). These tiny cells help nerve cells recover from damage, such as stroke.


Promote the absorption of fat-soluble nutrients

Bile salts enable the body to break down and better absorb fat-soluble vitamins such as vitamins A, D, E, and K. TUDCA increases bile production and improves the body’s ability to absorb fat-soluble vitamins.


Protect the liver

Taurodeoxycholic acid (TUDCA) and ursodeoxycholic acid (UDCA) are bile acid supplements that can help promote liver health, even in people with liver disease. Cirrhosis is a complication of advanced liver disease caused by alcohol abuse, hepatitis, or fatty liver disease (obesity or diabetes).

Elevated liver enzymes (including ALT, AST, and ALP) indicate changes in liver function. Studies have found that TUDCA can significantly reduce serum liver enzymes.

Bile salts act like detergent; when it comes back, it’s a strong irritant that can cause abdominal bloating, swelling, and pain.


Supports insulin sensitivity

Insulin sensitivity occurs when the body’s cells fail to respond appropriately to insulin. As a result, cells have difficulty absorbing blood sugar. A small four-week study involving people with insulin resistance showed that taking TUDCA daily improved insulin sensitivity by 30%.


Improves retinal health and vision

An important part of vision, the retina is a layer at the back of the eye that converts light into electrical signals and sends them to the brain to interpret what you see.


Vitamin A is a fat-soluble vitamin; it is absorbed along with dietary fat and stored in the liver and fat tissue of the body. Vitamin A has long been known for its ability to promote eye health. Without vitamin A, people can suffer from night blindness.

TUDCA improves vision because it promotes the proper breakdown and absorption of vitamin A.


Protect the nervous system

TUDCA has shown promise for its neuroprotective benefits, working to protect the nervous system and significantly improve neurological function after stroke.

Compelling scientific evidence shows that TUDCA helps reduce amyloid plaques, the cause of Alzheimer’s disease. TUDCA can reduce amyloid plaques in the brain even after the onset of Alzheimer’s disease produce.

TUDCA is considered a potential future treatment for neurological diseases such as Huntington’s disease, Parkinson’s disease and Alzheimer’s disease.


Acts as an antioxidant

TUDCA acts as a powerful antioxidant that fights the toxins that build up in the body from smoking and exposure to other toxins and pollutants.


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